درخت حوزه‌های تخصصی

Background: Expression of mucosal levels would affect the function of internal organs of the body and the digestive system, such as by creating a blockage for the progression of cancerous tumors and the failure of the target tissue, especially the large intestine. Aim : The purpose of this sudy was to investigate the effect of 8 weeks of quercetin supplementation and intermittent exercise on protein levels of intestinal Muc5Ac, Muc4 and polyphosphate in rats with colon cancer. Material and Methods: Tewenty-four rats were randomly assigned into four groups including quercetin (n=6), exercise (n=6), quercetin + exercise (n=6) and control group (n=6). Colon cancer induction was provided with the use of 1,2-dimethylhydrazine for 8 weeks and daily quercetin supplementation of 50 mg/kg body weight of mice by Gavagene method. Exercise protocol was performed 5 sessions per week with intensity of 60-70%, maximum speed of 23 m/min with 2-min rest in 8 weeks. ANOVA was used to analyze data. The level of significance was set at P <0.05. Results: It was suggested that there was a significant difference in protein levels of intestinal Muc5Ac, Muc4 and polyphosphate in all groups ( P <0.05). Furthermore, it was also indicated that Muc5Ac levels was significantly higher in the quercetin+ exercise group other than pther groups ( P <0.05). Conclusions: It was concluded that intermittent exercise and quercetin supplementation would increase the levels of Muc5Ac and Muc4 proteins in the large intestine of mice with colon cancer.  

Purpose: Diabetes mellitus is the most common metabolic problem worldwide, which is associated with hyperglycemia and structural and functional disorders of the nervous system. The aim of the present study was to investigate the effect of endurance training on serum glucose levels, weight changes and Like Growth Factor 1 (IGF-1) protein expression in the hippocampus of diabetic rats. Method: For this study, the samples included 48 male Wistar rats (8 weeks old), which were divided into 4 groups: control (C), the diabetes control (DC), diabetes-training (DT) and exercise (T). In order to induce diabetes, streptozotocin injection was used. 5 sessions per week of endurance activity were performed for 6 weeks. 48 hours after the completion of the exercise program, hippocampal tissue was dissected and extracted. ELISA method and one-way variance test were used to analyze the data. Resalts: Based on the results, serum glucose levels decreased after six weeks of endurance training (p=0.001). The amount of IGF-1 in group DC was significantly lower compared to all groups DT, T, and C (P≤0.05). But the DT group had no significant difference with the C and T groups (P=0.210 and P=0.226, respectively). On the other hand, the amount of IGF-1 in group T was only significantly different from group D (P=0.001). The correlation between blood glucose and IGF-1 was significant (p=0.001, r=0.820). Conclusion: Diabetes reduces IGF-1 and hyperglycemia, but exercise moderates the effect of diabetes on IGF-1. Considering the appropriate duration of training and the correlation of this protein with blood glucose, maybe endurance training can reduce the negative effect of diabetes.

Muscle weakness and shortness have a profound effect on the length and function of the body, causing abnormal pressure on the joints and other tissues. Deficiency or increase in flexibility is a factor in the stiffness and instability of moving parts and affects the maintenance of the desired condition. Therefore, the aim of this study was to compare the flexibility of Iranian adolescents and young people in two selected groups with healthy and spinal deformity. The statistical population of this study consisted of adolescents and young people across the country. The statistical sample consisted of 1263 girls and boys (with age range of 18-12 years old) from 5 geographical regions of the country, which could represent the whole country in terms of environment, culture, economy, and genetics and accounted for about 50% of the country's population. The flexible ruler was used to measure the arches of the spine in the sagittal plane, and the flexibility of the back and lumbar muscles, the trunk flexor muscles, and the trunk lateral flexor muscles were measured. The results showed that there was a significant difference between the flexibility of the two groups of kyphotic and kypholordotic with healthy subjects among the adolescents and young girls, and adolescent boys (P<0.05), but in the two groups, lordotic and healthy, this difference was not significant (P>0.05). The flexibility was significantly different between the gender in both the kyphotic and kypholordotic groups among adolescents (P<0.05), but in the healthy and lordotic groups was not significant (P>0.05). Finally, the results showed that there was only a significant difference between the flexibility of young girls with kyphotics and kypholordotics compared with h

During the Covid-19 pandemic, the use of online sports programs became popular. The purpose of this study was to investigate the effect of eight weeks of online body balance program on anxiety, depression, and aggression of children with attention deficit/hyperactivity disorder (ADHD). Body balance is a sport based on yoga, tai chi, and Pilates. The present study was a semi-experimental and applied type of study. The participants of the present study were 30 volunteer children with ADHD who were divided into two experimental (15 people) and control (15 people) groups by random assignment method. Aggression, depression, and anxiety variables were evaluated by Bass and Perry questionnaire, Maria Kvas children's depression questionnaire, and Revised Children's Manifest Anxiety Scale. The experimental group performed online body balance training for 8 weeks (3 sessions per week for 60 minutes) online, and the control group did their current activities. In order to investigate intra-group and inter-group differences, repeated measures ANOVA at the error level of 0.05 was used by SPSS software. The results showed there was significant difference in the average level of symptoms of depression, anxiety and aggression in the pre-test and post-test stages (P≤0.05), between the two control and experimental groups (P≤0.05) and the interaction effect of time and group (P≤0.05). The results of Tukey's test showed that there was a significant reduction of these symptoms between the two experimental and control groups in the variables of depression symptoms (-5.500), anxiety symptoms (-5.133) and aggression symptoms (-13.133). Based on the results of this research, eight weeks of body balance training reduced depression, aggression and anxiety symptoms in 7-9 year old children with attention deficit/hyperactivity disorder. Therefore, the improvement of mental disorders caused by this disease in children following the body balance exercise program emphasizes the importance of using this intervention method for children with ADHD.