درخت حوزه‌های تخصصی

Background: Expression of mucosal levels would affect the function of internal organs of the body and the digestive system, such as by creating a blockage for the progression of cancerous tumors and the failure of the target tissue, especially the large intestine. Aim : The purpose of this sudy was to investigate the effect of 8 weeks of quercetin supplementation and intermittent exercise on protein levels of intestinal Muc5Ac, Muc4 and polyphosphate in rats with colon cancer. Material and Methods: Tewenty-four rats were randomly assigned into four groups including quercetin (n=6), exercise (n=6), quercetin + exercise (n=6) and control group (n=6). Colon cancer induction was provided with the use of 1,2-dimethylhydrazine for 8 weeks and daily quercetin supplementation of 50 mg/kg body weight of mice by Gavagene method. Exercise protocol was performed 5 sessions per week with intensity of 60-70%, maximum speed of 23 m/min with 2-min rest in 8 weeks. ANOVA was used to analyze data. The level of significance was set at P <0.05. Results: It was suggested that there was a significant difference in protein levels of intestinal Muc5Ac, Muc4 and polyphosphate in all groups ( P <0.05). Furthermore, it was also indicated that Muc5Ac levels was significantly higher in the quercetin+ exercise group other than pther groups ( P <0.05). Conclusions: It was concluded that intermittent exercise and quercetin supplementation would increase the levels of Muc5Ac and Muc4 proteins in the large intestine of mice with colon cancer.  

Purpose: The aim of this study was to investigate the effect of 8-weeks endurance training on volume and capacity of lungs (forced expiratory volume in 1second, Forced vital capacity, ratio FEV1/FVC) and its relationship with BMI in Male Smoking students. Method: In order to accomplish this research 20 cigarette addicted men students referred to the smoking cessation clinic were randomly selected and were divided into two groups of experimental (n=10) (age: 15.33 ± 2.07 years and BMI: 25.41 ± 3.55 kg/m2) and the control group (n = 10) (age: 15.10 ± 2.81 years and BMI: 27.26 ± 66 kg/m2). The Spirometry indexes (FEV1/FVC, FEV1, FVC), height and weight were measured Prior and after 8-weeks of endurance training. Experimental group performed 8-weeks of progressive endurance training (3 sessions per week, 60 minutes per session) which included running with the intensity of 75% MHR. Intensity of exercise was controlled by maximum heart rate and the formula of (220-age) and the intensity level and duration of exercises increased in each session. Data analysis was done by using the variance analysis method for repetitive data and the independent T-test. Results: The results of this study showed that after eight weeks of endurance training, Spirometry indexes (FEV1/FVC, FEV1, FVC) significantly increased (P<0.05), and this increase had a negative relation with BMI (P<0.05, r=-0.62). Conclusion: the study showed that eight weeks of moderate-intensity endurance training improved volume and lung capacity of Male Smoking students and it could partly remove the damaging effects of smoking on physical and psychological health and it can help them quit smoking as well.

The purpose of this study is to compare the performance indicators between different football positions using the Global Positioning System (GPS) in Iranian Premier League football players. This is quasi-experimental study. To conduct this research, 18 football players who are members of a club in the Iranian Premier League were selected as the available sample, and the players were divided into 6 groups based on the game post. Then the data related to the players' performance (total distance, distance traveled with maximum speed, duration of maximum speed, maximum speed, sprints, number of accelerations, and number of decelerations) in 6 consecutive matches Collected using Global Positioning System (GPS). Also, one-way ANOVA analysis and SPSS software were used for data analysis at a significant level (α = 0.05). Based on the findings of the present study, between different football positions for the variables of total distance (P≤0.00), distance traveled at maximum speed (P≤0.00), duration of maximum speed (P≤0.00), maximum speed (P≤0.00), sprints (P≤0.00), number of accelerations (P≤0.00) and number of decelerations (P≤0.00) there are significant differences. There are many fundamental differences between the performance indicators of different football positions with each other it is necessary to recognize these differences and it is necessary to consider special exercises according to the physiological needs of each post.

Purpose: Type 2 diabetes is one of the most important metabolic disorders that different societies are facing with increasing prevalence. Aerobic exercises are a common type of exercise that reduces the levels of triglycerides and low-density lipoproteins and regulates blood pressure. The purpose of the research is to investigate the effect of 12 weeks of aerobic exercise on fasting glucose and several serum indicators of cardiovascular disease, in women with type 2 diabetes. Methods: In 2023, 20 women who referred to the Hamadan Diabetes Association voluntarily participated as subjects in this research and were randomly assigned to aerobic (10 people) and control (10 people) groups. The exercise program of the aerobic group included 3 running sessions per week with an intensity of 60-70% of the maximum heart rate for 12 weeks. In order to measure fasting blood glucose, glycosylated hemoglobin (HbA1c) and lipid profile [low-density lipoprotein (LDL-c), triglycerides (TG), High-density lipoprotein (HDL-c)], blood sampling was done before and after 12 weeks of exercise program. SPSS software and Kologrov Smirnov and Student's t test were used to check and analyze the data. Results: The results indicated that after 12 weeks of aerobic exercise, HbA1c (P=0/027), LDL-c (P=0/012) and fasting blood glucose (P=0/043) decreased significantly in the aerobic group. But no significant changes were observed in HDL-c and BMI. Conclusion: The results of this research showed that performing aerobic exercises leads to a decrease in HbA1c, fasting blood glucose and improvement in lipid profile, so it can probably be a useful way of treatment and prevention of cardiovascular diseases in type 2 diabetic patients.

The phenomena of fatigue of voluntary muscular effort is intricate and multidimensional in the field of sports sciences. The causes and effects of exercise-induced fatigue have been extensively studied, but the central nervous system's (CNS) involvement in this process is still unclear. In order to understand CNS fatigue after physical activity, the current review will examine changes in neurotransmitter function during exercise. Using primary sources such scientific journals and websites, a consensus and critical evaluation were carried out in order to accomplish this goal. For a number of neurotransmitters, including dopamine and serotonin (5-HT; 5-hydroxytryptamine), hypotheses have been established. The most well-known one is a rise in serotonin levels throughout the brain. Nutritional interventions intended to reduce brain serotonin synthesis during extended exercise enhance endurance performance, and there is strong evidence that increases and decreases in brain serotonin activity during prolonged exercise, respectively, accelerate and delay fatigue. There are several physiologically connected causes of fatigue. It is important to better understand how CNS effects affect fatigue in order to achieve maximum muscle performance in both daily life and athletics.