زهرا زندیه

Purpose: The objective of this study is to analyse various articles on the effect of various types of exercise on the angiopoietins family and angiopoietin-like proteins (ANGPTLs). Methods: PubMed, Science Direct, Scopus and Google Scholar databases were searched from 2000 to September 2020. After screening the articles, 19 articles that met the inclusion criteria were studied and analysed. Results: In our body, four types of angiopoietin and eight types of angiopoietin-like proteins have been identified, the functional method of some of them which are still not entirely understood. Angiopoietin-1 and angiopoietin-2 are essential regulators of vascular formation and maintenance. Angiopoietin-1 is found in perivascular and vascular cells within and around smooth muscle cells and plays an important role in growth, vascular stability, and pathological angiogenesis. On the other hand, angiopoietin-2 and angiopoietin-3 are mainly involved in inducing vascular regression, cell death, and inflammation. Angiopoietin-4, like angiopoietin-1, is responsible for the maturation, stabilization, and stasis of blood vessels. Conclusion: Studies show that exercise has a significant effect on increasing capillary density in the human body by increasing angiopoietin as one of the angiogenesis factors. In addition, there are many other benefits such as contribution to fat burning and treatment of coronary artery disease, cancer, asthma, and ischemia. More research is needed on the effects of different types of exercise training on angiopoietins.

SUBJECT AND OBJECTIVES : Due to the outbreak of a virus from the corona family called Covid-19, which has infected millions of people around the world, the subject of the possibility or impossibility of Government responsibility for infectious diseases is a global issue. It is the Government's duty to act in order to improve human life, and this is in accordance with its existential philosophy. This debate originates from the capabilities and powers that are monopolized by Government. It is believed that, by resorting to the authority and discretions of a conventional Government, it can prevent the spread of many infectious diseases to a large extent and in case of negligence in performing tasks, must be liable. This is the initial question: Why should the Government be liable for infectious disease which it had no role in creating it? METHOD AND FINDING : In this paper, by descriptive and analytical method and by collecting library resources, the continuity and relation between the responsibility of the Government and infectious diseases will be discussed. The Right to Life and the Right to Health are the basis of legal authority to intervene in the field of infectious diseases. CONCLUSION : Public Law and Human Rights has a special view of infectious diseases and some statutes provide for Emergency Situations. Governments are committed to taking the most effective measures possible to prevent spread of infectious diseases. According to the findings of this study, during Corona, these liabilities for the Government can be enumerated: Identification, Determining the liable authorities and institution, Education, Responsibility for prevention and treatment, Establish and expand insurance protections, Compensation for victims, Judicial and political Responsibility. In Iran, it is necessary to design a comprehensive system for exceptional situations such as pandemics.