aging

Purpose: On the other hand, fatigue is one of the most important indicators of aging syndrome. This study aimed to investigate the relationship between the level of physical activity and fatigue in elderly residents of rest homes in Tehran. Method: This was a descriptive correlational study in which 20 rest homes located in Tehran province constituted the study population. By visiting rest homes, the eligible subjects were chosen. Physical activity was measured by the Physical Activity Scale for the Elderly (PASE). The FACIT Fatigue Scale is a short, 13-item, easy to administer tool that measures an individual’s level of fatigue during their usual daily activities over the past week. Nutritional status was evaluated by mini nutritional assessment (MNA). Results: The results of statistical analysis indicated a significant and positive correlation between PASE and FACIT scores (r=0.48, p<0.01) while, there was a significant negative correlation between FACIT score and age (r=-0.23, p<0.01). Also, there was a significant positive correlation between MNA and FACIT (r=0.40, p<0.01). In addition, a significant positive correlation was found between MNA and PASE score (r=0.31, p<0.01). Conclusions: The findings of this study indicate that holding sports classes under the supervision of exercise physiologists is an essential matter to increase health and prevent age-related complications in elderly residents of Tehran rest homes.

Loss of balance and postural control are the main reasons for falls among the elderly adults that are considered as serious elderly health challenges with high impacts on the quality of life. The cerebellum is involved in postural control as one of the key neural structures that receives many inputs from the sensory systems. Cerebellar transcranial direct current stimulation (ctDCS) is a popular noninvasive and safe method enabling the adjustment of cerebellar activity. Therefore, we investigated the effect of ctDCS on postural control variables among elderly population with a history of stroke. Thirty elderly individuals (60-75 years) participated in this study. After preliminary assessments of postural control strategies by post urography at six sensory conditions, they received five 20-min sessions of active ctDCS at 2mA (intervention, n = 15) or sham stimulation (control, n = 15) in a random manner. At the end of the stimulation process, postural control strategies were reassessed. After adjustment for pre-test values using the ANCOVA test, an improvement of the subjects' performance in the first four conditions was observed in the intervention group compared with the control group (P < 0.05). However, in the fifth (P = 0.24) and sixth (P = 0.58) conditions, there were no significant differences between the groups. The results of this study showed the significant effect of ctDCS on the postural control strategies. These improvements were reflected by normalization of strategy of postural control in elderly adults.

Background: Telomerase activity plays a key role in preserving telomere length which is important in cellular aging. There is evidence showing the link between sirt6, irisin, and telomerase activity.   Aim : The aim of this study was to compare the effect of 8 weeks of high-intensity interval training (HIIT) and aerobic continuous training (ACT) on telomerase activity, sirt6, and irisin levels of healthy older adults. Materials and Methods: Thirty healthy males (age: 60-70 years, weight: 68-72 kg) participated voluntarily to follow the 8-week program including 3 sessions per week. Rest ratio in HIIT training was 1:2 and the intensity corresponded to 90% of HRR. ACT intensity was progressive starting with 50% of HRR and finishing with 70% of HRR. Blood samples were taken in a 12-hour fasting situation, before and after the program. Results: Results showed a significant effect of training on serum telomerase and sirt6 in training groups, not the control group. Also, in comparison to ACT and the control group, serum irisin was significantly higher in the HIIT group. Conclusion: We concluded HIIT training is safe and efficient for older adults in terms of telomerase activity, sirt6, and irisin level and can be followed as a time-efficient training protocol.

Purpose: On the other hand, fatigue is one of the most important indicators of aging syndrome. This study aimed to investigate the relationship between the level of physical activity and fatigue in elderly residents of rest homes in Tehran. Method: This was a descriptive correlational study in which 20 rest homes located in Tehran province constituted the study population. By visiting rest homes, the eligible subjects were chosen. Physical activity was measured by the Physical Activity Scale for the Elderly (PASE). The FACIT Fatigue Scale is a short, 13-item, easy to administer tool that measures an individual’s level of fatigue during their usual daily activities over the past week. Nutritional status was evaluated by mini nutritional assessment (MNA). Results: The results of statistical analysis indicated a significant and positive correlation between PASE and FACIT scores (r=0.48, p<0.01) while, there was a significant negative correlation between FACIT score and age (r=-0.23, p<0.01). Also, there was a significant positive correlation between MNA and FACIT (r=0.40, p<0.01). In addition, a significant positive correlation was found between MNA and PASE score (r=0.31, p<0.01). Conclusions: The findings of this study indicate that holding sports classes under the supervision of exercise physiologists is an essential matter to increase health and prevent age-related complications in elderly residents of Tehran rest homes.

Fatigue is a common and debilitating symptom among older adults, significantly impacting their quality of life and functional capacity. The relationship between serotonin and fatigue in aging is complex, involving multiple neurobiological pathways that influence sleep, mood, cognitive function, and energy metabolism. Understanding these mechanisms is crucial for developing effective management strategies. This review aims to elucidate the role of serotonin in the development of fatigue in elderly individuals and evaluate potential therapeutic strategies to mitigate this condition. A comprehensive review of recent literature was conducted, focusing on the neurobiological mechanisms linking serotonin to fatigue, the efficacy of pharmacological and non-pharmacological interventions, and future research directions. Studies were selected based on their relevance to serotonin’s role in aging and fatigue management. Serotonin plays a critical role in regulating various physiological and psychological functions that impact fatigue. Age-related declines in serotonin synthesis, receptor sensitivity, and transporter function contribute to increased fatigue through disrupted sleep, mood disorders, cognitive decline, and altered energy metabolism. Pharmacological treatments, including selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), have shown efficacy in alleviating fatigue related to depression and chronic pain. Non-pharmacological interventions, such as cognitive behavioral therapy (CBT), exercise, sleep hygiene, and dietary modifications, are also effective in managing fatigue. Combining these approaches may offer the best outcomes for elderly patients. Addressing fatigue in older adults requires a multifaceted approach that integrates both pharmacological and non-pharmacological strategies. Personalized treatment plans considering individual patient profiles and preferences can enhance therapeutic efficacy. Future research should focus on exploring novel therapeutic targets within the serotonergic system, developing personalized medicine approaches, and evaluating the long-term impact of combined therapies.

Purpose: In this study, we investigated the effects of resistance training types on clinical and functional indices in older individuals with Osteosarcopenia. Method: In this Systematic Review study, a systematic searching strategy was used in information databases such as Pub Med, Web of Science, Scopus, Google Scholar, Cochrane, and Ambace, all of the studies were extracted by using specific keywords such as Strength exercise, Exercise training, Resistance exercise, Resistance training, Strength training, Physical activity, Osteosarcopenia, Aging, Older adult, Elderly which were published on 7th August 2023. After all preliminary screening, surveying of complete text, and assessment of critical studies, scrutinized articles were related to inclusion criteria. Finally, 17 papers were selected for this study. Results: According to the present study, Resistance training for Osteosarcopenia older individuals has an effective result to improve Osteosarcopenia risk factors, and older patients’ performance and clinical status. However, it has to be mentioned that it needs further study in the contexts of Resistance training and Osteosarcopenia syndrome in elderly adults. Conclusion: Resistance exercise training has markedly beneficial effects on elderly patients with Osteosarcopenia which improves Sarcopenia risk factors, and older patients’ performance, clinical status and function of elderly patients.

Objective: This study aimed to present a structural model of the quality of life for the elderly based on self-care with the mediating role of social support. Methods: The research employed a correlational design using structural equation modeling. The study population consisted of individuals aged 60 to 75 years living in urban homes in Tehran, with 314 participants selected as the research sample. The data collection tools included the Iranian version of the Phillips Social Support Questionnaire (1986), the World Health Organization's Quality of Life Questionnaire (1989), and the Elderly Self-care Questionnaire by Younesi et al. (2020). The statistical technique used was a full latent variable structural equation model, and the data analysis was performed using SPSS version 26, AMOS version 24, and R software version 4.3.1. Examination of the model fit indices indicated that the model overall is in excellent condition for explaining and fitting the data. Findings: The results showed that both social support and self-care have a significant positive effect on the quality of life variable for the elderly. Moreover, the self-care variable also has a significant positive impact on the social support variable at a 95% confidence level. Additionally, the self-care variable significantly affects the quality of life of the elderly through the mediating variable of social support. Conclusion: According to the findings of this study, the mediating role of social support can play a significant role in examining changes in the quality of life of the elderly. It is recommended that the importance of social support be emphasized and taught in elderly care centers and other counseling and guidance centers.

Aging is influenced by a wide range of biological processes, with increasing attention focused on physical exercise as an effective, non-pharmacological intervention to support healthy aging and extend lifespan. This review examines how exercise influences aging mechanisms by activating Forkhead Box O (FOXO) proteins—especially FOXO3, a critical regulator of oxidative stress resistance, metabolism, and cellular repair. By integrating evidence from both animal models and human studies, we explore how different types of physical activity, including endurance and resistance training, enhance FOXO signaling pathways that govern mitochondrial health, autophagy, and inflammation control. FOXO activation appears to play a central role in mitigating age-related diseases such as sarcopenia, cardiovascular disease, neurodegeneration, and cancer. While preclinical studies consistently demonstrate these protective effects, human data are more variable, highlighting the influence of age, sex, and intervention type. Understanding the molecular connection between exercise and FOXO activity can help develop targeted exercise recommendations to promote longevity and delay age-associated functional decline.

Objective : Given the growing elderly population in Iran and the relationship between physical literacy and health, assessing physical literacy in this population is important. However, there are limited studies on the assessment of physical literacy in the elderly. The present study aimed to examine the cross-cultural validity of the Persian version of Senior Perceived Physical Literacy Instrument (SPPLI). Method: At first, the translation/back translation process and content validity were carried out through the Content Validity Index (CVI) with opinion of five experts. Subsequently, concurrent and construct (age differences and convergent) validity, and internal consistency were examined in a sample of 78 older adults (aged 60–90 years) randomly selected from nursing homes and physiotherapy centers in Qazvin. Construct validity of the SPPLI was assessed by comparing age-related differences and its correlation with age and its convergent validity with the Physical Activity Scale for the Elderly (PASE) and the short-form Falls Efficacy Scale-International (FES-I) and concurrent validity was evaluated through the its relationship with the Senior Fitness Test (SFT) as a measure of actual physical literacy. Results : The CVI results confirmed the content validity of all SPPLI items. The results of Mann-Whitney U test revealed no significant difference in perceived physical literacy between the two age groups (p = 0.42). Spearman’s correlation between total scores of SPPLI and age was weak and non-significant (r (78) = 0.123). The Spearman correlation coefficients of SPPLI with total scores of SFT, PASE, and short FES-I were 0.501, 0.452, and -0.001, respectively. Conclusions : The content and concurrent validity of the SPPLI was confirmed, and its internal consistency was good. However, convergent validity was moderate with the PASE and very weak with the short FES-I, while construct validity based on age differences was not confirmed. In conclusion, the Persian SPPLI exhibits appropriate cross-cultural validity.