Exercise Training

Purpose: The objective of this study is to analyse various articles on the effect of various types of exercise on the angiopoietins family and angiopoietin-like proteins (ANGPTLs). Methods: PubMed, Science Direct, Scopus and Google Scholar databases were searched from 2000 to September 2020. After screening the articles, 19 articles that met the inclusion criteria were studied and analysed. Results: In our body, four types of angiopoietin and eight types of angiopoietin-like proteins have been identified, the functional method of some of them which are still not entirely understood. Angiopoietin-1 and angiopoietin-2 are essential regulators of vascular formation and maintenance. Angiopoietin-1 is found in perivascular and vascular cells within and around smooth muscle cells and plays an important role in growth, vascular stability, and pathological angiogenesis. On the other hand, angiopoietin-2 and angiopoietin-3 are mainly involved in inducing vascular regression, cell death, and inflammation. Angiopoietin-4, like angiopoietin-1, is responsible for the maturation, stabilization, and stasis of blood vessels. Conclusion: Studies show that exercise has a significant effect on increasing capillary density in the human body by increasing angiopoietin as one of the angiogenesis factors. In addition, there are many other benefits such as contribution to fat burning and treatment of coronary artery disease, cancer, asthma, and ischemia. More research is needed on the effects of different types of exercise training on angiopoietins.

The first report showing that long-term endurance exercise increases oxidative stress in humans was published more than 4 decades ago. Since this discovery, many subsequent studies have confirmed the fact that muscle activity increases the production of reactive oxygen species (ROS) and leads to oxidative stress in multiple tissues, including blood and skeletal muscle. Although several tissues may contribute to exercise-induced ROS production, muscle contractions are predicted to stimulate ROS production in active muscle fibers, and skeletal muscle is the major source of ROS production during exercise. This contraction-induced ROS production is associated with 1. oxidant damage in several tissues (eg, increased protein oxidation and lipid peroxidation), 2. accelerated muscle fatigue, and 3. activation of biochemical signaling pathways leading to adaptation. Exercise helps in tight muscle fibers, it is related. While our understanding of exercise and oxidative stress has advanced rapidly over the past decades, questions remain as to whether exercise-induced increased ROS production is beneficial or detrimental to health. This review addresses this issue by discussing the site(s) of oxidant production during exercise and detailing the health consequences of exercise-induced ROS production.

Purpose: In this study, we investigated the effects of resistance training types on clinical and functional indices in older individuals with Osteosarcopenia. Method: In this Systematic Review study, a systematic searching strategy was used in information databases such as Pub Med, Web of Science, Scopus, Google Scholar, Cochrane, and Ambace, all of the studies were extracted by using specific keywords such as Strength exercise, Exercise training, Resistance exercise, Resistance training, Strength training, Physical activity, Osteosarcopenia, Aging, Older adult, Elderly which were published on 7th August 2023. After all preliminary screening, surveying of complete text, and assessment of critical studies, scrutinized articles were related to inclusion criteria. Finally, 17 papers were selected for this study. Results: According to the present study, Resistance training for Osteosarcopenia older individuals has an effective result to improve Osteosarcopenia risk factors, and older patients’ performance and clinical status. However, it has to be mentioned that it needs further study in the contexts of Resistance training and Osteosarcopenia syndrome in elderly adults. Conclusion: Resistance exercise training has markedly beneficial effects on elderly patients with Osteosarcopenia which improves Sarcopenia risk factors, and older patients’ performance, clinical status and function of elderly patients.

Background: Metabolic diseases such as type 1 diabetes is considered the most important threat factor for cardiovascular complaint. Although the pathological mechanisms underpinning the development of T1D are delicate to define, better understanding of the molecular aspects is most important to identify new remedial targets.Aim: Evaluating of the effect of two selected resistance and recreational sport activities on microRNA-148a expression and some biomarkers in children with type 1 diabetes.Materials and Methods: Twenty type 1 diabetic children were assigned randomly to resistance exercise (RE), (n=10, age=12.6 years), and recreational sport activities (RSA), (n=10, age=12.4 years) groups. Participants engaged in an 8-week exercise training, 3 sessions/week. The miR-148-a, HbA1c, glucose, insulin, and HOMA-IR levels have been assessed before and after exercise interventions.Results: Following the exercise interventions, the concentration of miR-148-a exhibited a non-significant increase in both groups. Nevertheless, no significant differences were noted in the reduction of insulin resistance or in the levels of insulin itself (P≤ 0.05). The level of HbA1c decreased but the cardio-respiratory endurance of subjects increased.Conclusion: Both the resistance and recreational sport activities were effective to improve in cardiorespiratory fitness, diabetic markers, and miR-148a changes that seem to be indicative of the pathological status of type 1 diabetic children.