In this article, we seek to investigate what cultural invasion is and ways to deal with it in The Supreme leader's thought, emphasizing on media invasion. The research method is descriptive-analytical, and the collection of information is done by library-document method. The findings of this research show that The Supreme leader considers the cultural invasion of the West to the foundations of Islamic beliefs and to the corruption and destruction of Islamic societies. To deal with the cultural invasion, he suggests a correct knowledge of the enemy and a rational and logical defense of the right. At the level of media attack, his emphasis is to counter Western cultural and media propaganda through satellite networks and especially Hollywood, and considers the way to counter it to be paying attention to Islamic culture, promoting religious models, and encouraging young artists and believers in the field of art. As a result, the solution to deal with the cultural invasion should be followed by policies in the cultural and media arena, which can be mentioned as follows: creating national self-confidence through the display of the country's authority, unity and security by the responsible institutions, especially the radio and television, showing convergence and solidarity as a prominent cultural characteristic of Iranians, especially against the foreign enemy, high-lighting the commonalities of ethnic identity with Iran's national identity, attention to the Iranian-Islamic style in life according to the emphasis of the Supreme Leader, providing awareness in the field of divisive satellite networks and paying special attention to Iranian art, especially music, which has a high power of attraction among young people.