Resilience is a psychological characteristic that enables individuals to return to their normal lives after experiencing adversity and stressful situations, thereby preventing feelings of failure and defeat in life. In medical communities, due to high-pressure job demands and environmental stressors, resilience is considered one of the most critical components of psychological well-being, closely linked to one’s professional role and job satisfaction. In this regard, the present study investigates the effect of the Five Major Personality Factors on resilience, with the mediating role of cognitive emotion regulation. The statistical population consisted of physicians working at Imam Reza Hospital in Tabriz during the second half of the 2024-2025 academic year. Following the acquisition of the ethics approval code (IR.IAU.TABRIZ.REC.14040.182) a sample of 384 individuals was selected based on Morgan's table through stratified random sampling with proportional allocation across four strata: internal medicine (male), internal medicine (female), neurology (male), and neurology (female), according to the actual distribution in the population. The participants completed the NEO Five-Factor Inventory (NEO-FFI; 1985), the Connor-Davidson Resilience Scale (CD-RISC; 2003), and the Cognitive Emotion Regulation Questionnaire (CERQ; Garnefski & Kraaij, 2006). Data were analyzed using structural equation modeling (SEM) with partial least squares (PLS) in Smart PLS software. The results indicated that all of the Five Major Personality Factors, except for openness to experience and agreeableness, had a significant effect on resilience. Moreover, all personality traits except agreeableness significantly influenced resilience through the mediating variable of cognitive emotion regulation. Based on these findings, it can be concluded that individuals’ level of resilience is influenced by their personality traits and the factors affecting their emotion regulation.
