This study investigated the impact of newly developed English for Specific Purposes (ESP) materials on enhancing Intercultural Communicative Competence (ICC) and cultural awareness among Iranian undergraduate psychology students. Addressing the need for culturally responsive communication and limitations of conventional materials, researchers designed a 5-unit coursebook based on Byram’s (1997) ICC framework and the ICC materials development framework proposed by Mishan and Kiss (2024). Employing a mixed-methods design over a 10-week semester, 60 homogeneous students were equally assigned into two groups: an experimental group received newly developed ESP materials that integrated cross-cultural case studies, dialogic activities, and culturally diverse psychological modules, while the control group used traditional textbooks. Quantitative data from ICC questionnaires revealed a significant increase in ICC within the experimental group. Qualitative analysis of student reflections and interviews indicated enhanced intercultural attitudes, knowledge, skills, and cultural awareness, reflecting meaningful shifts in perspectives for the experimental group. These findings underscore the effectiveness of ICC-focused ESP materials in preparing psychology students for culturally sensitive practice. The study contributes to the development of ESP materials by advocating for the intentional integration of intercultural competence to cultivate globally competent practitioners.